Humira (adalimumab) is a biologic medication used to treat autoimmune conditions by neutralizing the activity of tumor necrosis factor-alpha (TNF-alpha). It is a fully humanized monoclonal antibody administered as a subcutaneous (under the skin) injection. Data from clinical trials and patient experiences indicate its effectiveness in treating autoimmune diseases like Crohn’s disease, psoriasis, rheumatoid arthritis, and many others where TNF-alpha is involved.
Humira significantly improves the quality of life of autoimmune patients by reducing pain and swelling. It is also effective in managing skin symptoms of psoriasis and hidradenitis. For some patients, it can alleviate symptoms within two weeks. However, its effectiveness depends on how the disease responds to the Humira medication.
How Does Blocking TNF-alpha Help in Autoimmune Diseases?
TNF-alpha is an inflammation-promoting molecule released by the immune system when it detects stressed cells. In autoimmune conditions, overactive immune cells release too much TNF-alpha, which triggers the immune system to produce other mediators of inflammation to sustain the inflammation.
Moreover, TNF-alpha facilitates pathways involved in cell death and tissue remodeling (changes in overall tissue structure), such as joint deformities in rheumatoid arthritis. The structural changes and tissue damage in muscles and joints in rheumatoid arthritis and psoriatic arthritis are a few examples of tissue remodeling caused by TNF-alpha. Blocking TNF-alpha activity can slow disease progress and reduce the inflammation and tissue damage caused by the immune system.
Humira Uses and Dosages
Humira’s versatility and effectiveness make it a key treatment option for a range of autoimmune diseases. It can be used to treat the following autoimmune diseases.
Rheumatoid Arthritis
Humira is used to treat and manage the symptoms of rheumatoid arthritis by blocking TNF-alpha. It effectively reduces swelling, relieves joint pain, and minimizes joint damage. It can slow disease progression, improve joint mobility, and improve the overall quality of life.
The commonly prescribed dosage of Humira is 40 mg every other week when taken with methotrexate or weekly without methotrexate, as prescribed by the physician. Most patients can feel relief after 2 – 12 weeks of starting treatment for moderate to severe rheumatoid arthritis.
